Equine mesenchymal stem cell derived extracellular vesicle immunopathology biomarker discovery

The use of mesenchymal stem cells (MSCs) in human and veterinary clinical applications has become a subject increasing importance due to their roles immunomodulation regenerative processes. MSCs are especially relevant equine medicine because they may have the ability treat prevalent musculoskeletal disorders, among other conditions. However, recent evidence suggests that components secreted by MSCs, particularly extracellular vesicles (EVs), responsible for these properties. EVs contain proteins nucleic acids, which possess an active role intercellular communication can be used as therapeutics. intersection with remains relatively new field, there is demand identify biomarkers discern enrich therapeutic EVs, progressing efficacy. In this study, we identified characterized 84 miRNAs, between three donors involved cell EV subjects. We discovered distinct groups shared like miR-21-5p miR-451a, abundant enriched donors’ respectively. By mapping comparing MSC-EV miRNA expression, many pathways tissue processes related applications. Therefore, miRNAs highlighted article valuable screening MSC-derived potential therapy.